S4:E3 - London Calling ... Spirocycles

<p>This month we sit down with Damien Valette, Olivia Boyd and David Petrone to chat about their latest paper in Organic Letters on the desymmetrization of prochiral dienones to control all-carbon quaternary centers. This reaction leverages biocatalysis, specifically an ene-reductase [ERED] enzymes (which are making their second appearance on the pod - see <a href="https://open.spotify.com/episode/581wMz9NPLK8APMpu1VggG?si=MpgCKUMIRKmLMqe3NAT9EA" target="_blank" rel="ugc noopener noreferrer">S1:E5</a>).</p><p>David, Damien and Olivia walk us through the discovery of the reaction and why it's uniquely suited to set these challenging stereocenters. This work was done in the context of work at the med-chem/process interface which we explore as well.</p><p>Damien and Olivia hail from our London UK MSD site and give us details on the progress of our company's build in the region as well as chat with us about how to be successful when collaborating with scientists on another continent (David).</p><p><strong>Read the papers we discussed today:</strong></p><p><a href="https://pubs.acs.org/doi/10.1021/acs.orglett.4c04383" target="_blank" rel="ugc noopener noreferrer">HTE-Enabled Development of an Ene-Reductase-Catalyzed Desymmetrization: Remote Control of All-Carbon Quaternary γ-Centers</a> <a href="https://pubs.acs.org/doi/10.1021/acs.joc.4c02422?ref=pdf" target="_blank" rel="ugc noopener noreferrer">⁠</a>- Org Lett 2024</p><p>Follow the Pharm to Table podcast on X - ⁠⁠⁠⁠@PharmtoTablePod</p><p>⁠⁠⁠⁠Visit our website at <a href="⁠⁠⁠⁠https://podcasters.spotify.com/pod/show/pharm-to-table" target="_blank" rel="ugc noopener noreferrer">⁠⁠⁠⁠⁠https://podcasters.spotify.com/pod/show/pharm-to-table⁠</a> </p><p><br /></p>