Intertwined Biosciences: Engineering Evolution for Human Health

<p>Max Rye and Evan Appleton of Intertwined Bio join Galaxy Balance to explore one of the boldest ideas in modern biology: borrowing nature’s most extreme traits and translating them into human health.</p><p>From horses that resist liver cirrhosis to naked mole rats, bowhead whales, radiation resistant organisms, hibernating animals, and the future of humans in space, this conversation asks what becomes possible when evolution itself becomes a design library. Max and Evan explain how Intertwined Bio is using synthetic biology, gene editing, AI, virtual macrophages, and agentic systems to identify traits from extraordinary animals and test whether those adaptations can be engineered into human cells.</p><p>We discuss liver fibrosis, DNA damage repair, innate immune engineering, longevity, space radiation, de extinction, Colossal Biosciences, the future of virtual cells, and the ethical line between therapy and enhancement.</p><p>This is a conversation about turning science fiction into biology.</p><p>00:00 - Introduction to Intertwined Bio and their innovative approach</p><p>01:01 - The origins and motivations of Max and Evan in biotech</p><p>04:56 - Scientific foundation: Borrowing traits from long-lived and resilient animals</p><p>07:16 - Why now? Recent technological advances enabling these innovations</p><p>10:46 - Role of AI in understanding complex biological systems and virtual cell modeling</p><p>14:17 - Delivery strategies for genetic modifications in humans</p><p>18:19 - Regulatory pathways and ethical boundaries in gene editing</p><p>22:25 - The potential of junk DNA variants and regulatory engineering</p><p>27:09 - The potential impact on sports animals and broader applications</p><p>31:12 - Industry landscape, collaboration, and competition</p><p>33:21 - Building a startup: team dynamics, trust, and early steps</p><p>35:58 - Insights on other biotech ventures like AstroMech and their directions</p><p>38:39 - Space applications: radiation resistance, hibernation, and life support systems</p><p>43:01 - Prioritizing targets using AI and high-throughput screening</p><p>48:31 - Broader prospects: aging, longevity, and the OZEMPIC effect</p><p>52:44 - Focus on innate immune system engineering and virtual cell development</p><p>57:15 - Strategies for macrophage gene editing and cell type targeting</p><p>1:01:36 - Bottlenecks in lab throughput and cell growth limitations</p><p>1:04:30 - The influence of science fiction on biotech innovation and ethical outlooks</p><p>1:06:14 - Closing thoughts: science fiction as inspiration and the rapid transition of ideas into reality</p>