Dr. Colleen Cutcliffe, PhD: Natural GLP-1 Production, Fiber Deficiency, Akkermansia and the Gut Microbiome Connection

<p>Most people think of the gut as a digestive organ. It is not. It is the upstream controller of your metabolism, immune function, brain health, skin, and hormones and almost everyone is running it on a depleted, misfed microbiome without knowing it.</p><p>Dr. Colleen Cutcliffe, PhD is the co-founder and CEO of Pendulum Therapeutics, holds a PhD in biochemistry from Johns Hopkins, and spent over 15 years in pharma and biotech before pioneering next-generation probiotic science. Her team was the first in the world to manufacture Akkermansia, a strain found at high levels in virtually every centenarian population studied and depleted in almost every major chronic disease. </p><p>What makes this conversation different from most gut health discussions is the level of scientific rigor behind it. This is not wellness theory. This is published research, clinical data, and a decade of actually building the science from the ground up.</p><p>Join the most comprehensive *female-specific community for health and longevity optimization.* After over a decade dedicated to human performance and women’s health, I created this space to share everything you need to know to optimize health and lifespan. Inside, you’ll get access to exclusive protocols, live Q&amp;As, the latest female longevity science, and a private, supportive community of like-minded women.</p><p><a href="https://kayla-barnes-lentz.circle.so/checkout/become-a-member"><u>https://kayla-barnes-lentz.circle.so/checkout/become-a-member</u></a></p><p><strong>In this conversation we explore:</strong></p><ul><li><p>How your gut produces its own GLP-1 naturally and why synthetic versions may blunt that system over time</p></li><li><p>Why Akkermansia is elevated in centenarians and depleted across virtually every chronic disease</p></li><li><p>The fiber gap: 95% of people are under-threshold and it is driving metabolic and colon health decline</p></li><li><p>What early antibiotic use does to the microbiome and how to rebuild at any age</p></li><li><p>Why soap may be fueling the allergy and asthma epidemic by stripping the skin&#39;s protective barrier</p></li><li><p>How butyrate links gut health, colon cancer risk, and natural GLP-1 production</p></li><li><p>Why most probiotics on Amazon do not contain what the label claims</p></li></ul><p><strong>Connect with Kayla:</strong></p><p>Instagram:<a href="https://www.youtube.com/redirect?event=video_description&redir_token=QUFFLUhqbV9UTElwSGJwV243ZGFzS2Y4NGxWc3B6X2lZZ3xBQ3Jtc0tuVzhzdmFwR29tcXFiUzc4ZmtPVVZsNjNpNTFjSGhyZTBmSmZidy1tbmY5LVlqbXJWV1FMQ2NfREoyUFowZVBTc0hWRVkzT3N3d0hhLTdiNS1aRlFZVVI5NnZxR0dibFdzajM0X1E5YUJnWVU1MllVMA&q=https%3A%2F%2Fwww.instagram.com%2Fkaylabarnes%2F&v=2h58A7fzlMk"> </a><a href="https://www.instagram.com/kaylabarnes/"><u>https://www.instagram.com/kaylabarnes/</u></a></p><p>TikTok:<a href="https://www.youtube.com/redirect?event=video_description&redir_token=QUFFLUhqbUlkU2ZIWXRhdUd0dV9JalVzZzR4Sk51UlZzZ3xBQ3Jtc0tscG1rVTR6NGtJYjBBazcxS1lNdTZjTWVuMnFpbTJPRTFQei1HeGVKT1J2NXFSdGpFUjQzd0Q2QkhsclhsQWdvVTJ1a1g1anpaR3BxNXpqNkNrZGVZd19GQU5ySTZLVEV4d2hHMWxKT2pOMnV0eFVpOA&q=https%3A%2F%2Fwww.tiktok.com%2F%40femalelongevity&v=2h58A7fzlMk"> </a><a href="https://www.tiktok.com/@femalelongevity"><u>https://www.tiktok.com/@femalelongevity</u></a></p><p>Twitter:<a href="https://x.com/femalelongevity"><u>https://x.com/femalelongevity</u></a></p><p>Website:<a href="https://www.kaylabarnes.com/"><u>https://www.kaylabarnes.com/</u></a></p><p>Spotify: <a href="https://open.spotify.com/show/4OLWWn22RGB0argbRPvAaQ?si=8e91b3c9e0ce4054"><u>https://open.spotify.com/show/4OLWWn22RGB0argbRPvAaQ?si=8e91b3c9e0ce4054</u></a></p><p>Apple: <a href="https://podcasts.apple.com/us/podcast/longevity-optimization-with-kayla-barnes-lentz/id1591130227"><u>https://podcasts.apple.com/us/podcast/longevity-optimization-with-kayla-barnes-lentz/id1591130227</u></a></p><p>Follow Her Female Protocol:<a href="https://www.youtube.com/redirect?event=video_description&