I Changed My Mind About GLP-1s: What You Need to Know About Ozempic, HRT, and Longevity

Menopause Mastery | I Changed My Mind About GLP-1s: What You Need to Know About Ozempic, HRT, and Longevity  | Ep. 294 solocast with Dr. Betty Murray

🌿Welcome to The Menopause Mastery Show!

👉 What if midlife weight gain isn't a failure of willpower—but a biological shift that requires a different strategy?

In this episode of Menopause Mastery, Dr. Betty Murray is making a confession: She's changed my mind about GLP-1 medications. When medications like semaglutide and tirzepatide first exploded into mainstream culture, she was deeply skeptical—not because she doubted the underlying science, but because she was concerned about inappropriate prescribing, aggressive dosing, inadequate monitoring, and the lack of guidance around nutrition, protein, resistance training, and hormones.

Now, with more research and clinical experience available, the conversation has changed. We explore what GLP-1 medications may do beyond weight loss, including their relationship with inflammation, insulin sensitivity, cardiovascular health, and metabolic health—and why the midlife context matters.

We also dig into the potential role of combining GLP-1 therapy with hormone replacement therapy, the concerns around muscle loss and inadequate protein intake, why some clinicians are exploring lower-dose approaches, and what women should consider measuring before making decisions about metabolic health.

Most importantly, this episode is about precision rather than quick fixes. Your scale isn't the only measure of health. Muscle strength, body composition, bone density, metabolic markers, inflammation, hormones, and long-term health span all belong in the conversation.

Topics covered:

🔹 Why I changed my perspective on GLP-1 medications

🔹 What happens metabolically during perimenopause and menopause

🔹 GLP-1s and inflammation

🔹 GLP-1s, cardiovascular and kidney health