Leveraging the Million Veteran Program Dataset to Bring a Prostate Genomic Risk to the Clinic: the ProGRESS study

In this episode, we discuss the recent publication in Nature Cancer by Jason L. Vassy et al. on building a personalized genomic risk model to enhance precision in prostate cancer screening.

Guest Kara Maxwell, MD, PhD, from the University of Pennsylvania, explains how the PCARE test combines a polygenic risk score with genetic ancestry and family history to guide PSA decisions in clinical care. You'll hear how the Million Veteran Program enabled model development, why monogenic mutations were added to the clinical assay, and what the randomized PROGRESS trial will test about PSA screening pathways.