The Signal with Jonathan Jarecki

← The Signal with Jonathan Jarecki8 jun · 1 u 26 min

Light as a Nutrient: Sunlight, Circadian Rhythm & Metabolic Health | Dr. Max Gulhane

Light as a Nutrient: Sunlight, Circadian Rhythm & Metabolic Health | Dr. Max Gulhane8 jun1 u 26 min

<p>Dr. Max Gulhane (MD) is a practising family medicine physician and health-optimising physician with a passion for root-cause analysis of human chronic disease and longevity. We discuss the full solar spectrum and how ultraviolet, visible, blue, red and near-infrared light each affect human physiology, including the POMC pathway, nitric oxide and blood pressure, and the evidence on sunlight, skin cancer and the vitamin D paradox. We discuss how artificial light at night suppresses melatonin and disrupts the circadian control of DNA repair, cardiovascular health, and metabolism. For those interested in light and circadian health, Dr. Gulhane offers a grounded, mechanism-focused framework for aligning daily light exposure with human biology.<br /><br /><a rel="noopener noreferrer nofollow" href="https://docs.google.com/document/d/15zOnh_l6WOe6237CbQrFPkeoQjUZXIm9Ul4ncQTNXDQ/edit?usp=sharing" target="_blank">Full Show Notes here.</a> <br /><br />Thank you to our sponsor<br />Daylight Computer: <a rel="noopener noreferrer nofollow" href="http://daylightcomputer.com" target="_blank">daylightcomputer.com</a> (code JONATHANJ for $25 off)<br /><br />Dr. Max Gulhane<br />Website: <a rel="noopener noreferrer nofollow" href="https://www.drmaxgulhane.com/" target="_blank">https://www.drmaxgulhane.com/</a><br />Instagram: <a rel="noopener noreferrer nofollow" href="https://www.instagram.com/maxgulhanemd/" target="_blank">https://www.instagram.com/maxgulhanemd/</a><br />X: <a rel="noopener noreferrer nofollow" href="https://x.com/MaxGulhaneMD" target="_blank">https://x.com/MaxGulhaneMD</a><br />YouTube: <a rel="noopener noreferrer nofollow" href="https://www.youtube.com/@maxgulhanemd/" target="_blank">https://www.youtube.com/@maxgulhanemd/</a><br /><br />Recommended lectures:<br />Sunlight &amp; Cancer: Beyond Skin Deep — <a rel="noopener noreferrer nofollow" href="https://youtu.be/SJGvr6dGOgQ" target="_blank">https://youtu.be/SJGvr6dGOgQ</a><br />Artificial Light &amp; Diabetes: No Food Required — <a rel="noopener noreferrer nofollow" href="https://youtu.be/vgrFpPusSKU" target="_blank">https://youtu.be/vgrFpPusSKU</a><br />What Your Cardiologist Doesn't Know About Sunlight &amp; Heart Health — <a rel="noopener noreferrer nofollow" href="https://youtu.be/NaeqPHEM-d0" target="_blank">https://youtu.be/NaeqPHEM-d0</a><br /><br />Jonathan Jarecki<br />Instagram: <a rel="noopener noreferrer nofollow" href="https://www.instagram.com/jonathanjarecki/" target="_blank">https://www.instagram.com/jonathanjarecki/</a><br />X: <a rel="noopener noreferrer nofollow" href="https://x.com/jonathanjarecki" target="_blank">https://x.com/jonathanjarecki</a><br />Newsletter: <a rel="noopener noreferrer nofollow" href="https://jonathanjarecki.substack.com/?utm_campaign=profile_chips" target="_blank">https://jonathanjarecki.substack.com/?utm_campaign=profile_chips</a><br /><br />00:00 Intro<br />03:25 Dr. Max Gulhane<br />04:02 Dr. Gulhane's Love for Science and Medicine<br />09:01 What is Light?<br />12:52 Sunlight Broken Down as a Nutrient<br />14:02 Ultraviolet Light: Sunlight Is More Than Vitamin D<br />15:56 POMC<br />21:38 UVA/UVB on Cardiometabolic Health<br />24:40 Big Picture of UV Light<br />28:41 Sunlight, Skin Cancer, Dermatology Messaging, The Vitamin D Paradox<br />35:10 Blue Light, Artificial Light at Night (ALAN), Mechanisms<br />38:50 Sponsor: Daylight Computer<br />40:34 ALAN, Epidemiology, Cancer, Heart Disease<br />45:04 DNA Repair Mechanisms, Circadian Control<br />47:27 Melanopsin (OPN4), Blue Light, UV Susceptibility<br />53:25 Red, Infrared, Photobiomodulation, Metabolism<br />01:00:08 Blue Light, Metabolism, and the Built Environment<br />01:05:19 Photobiology of Atherosclerosis<br />01:10:11 Blue Light on Cardiovascular Function<br />01:12:25 Three M's of Circadian Health<br />01:18:43 Sunlight, Testosterone, and Reproductive Behavior<br />01:24:14 Support, YouTube, Spotify &amp; Apple Follow, Reviews &amp; Feedback, Social Media, Subst