EDITORS’ CHOICE: Human-relevant Ptpn6 mutation alters immune and hepatic functions during aging

A research paper recently published in Aging, titled “Human-relevant Ptpn6 mutation alters immune and hepatic functions during aging,” investigated how a human-relevant mutation in the PTPN6 gene, which encodes the immune and metabolic regulator SHP-1, affects immune and liver function during aging. Using mice carrying the mutation, the researchers found that older mutant mice had improved glucose tolerance and hepatic insulin sensitivity, but also developed liver abnormalities characterized by increased fibrosis and the accumulation of immune cells, particularly B lymphocytes and macrophages. Further analyses indicated that these age-related changes were driven primarily by altered immune activity rather than direct effects within liver cells.

The findings identify SHP-1 as an important regulator of liver immune homeostasis and provide new insight into how immune-cell infiltration may contribute to age-related changes in the liver.

DOI - https://doi.org/10.18632/aging.206413

Corresponding author - André Marette - andre.marette@criucpq.ulaval.ca

Abstract video - https://www.youtube.com/watch?v=lyn__UY9Buk

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Keywords - aging, SHP-1/Ptpn6, B cell, macrophage, aging, Ptpn6Ala457Thr

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ResearchGate - https://www.researchgate.net/journal/Aging-1945-4589