S3E13 - Resistance Guided Mycoplasma Genitalium Treatment

<p><strong>Welcome to Season 3 of AMC Clinical Deep Dive! </strong></p><p><br></p><p>Driven by alarming macrolide resistance (&gt;60% in Australia), <em>Mycoplasma genitalium</em> (M. gen.) management requires resistance-guided sequential therapy. This episode deconstructs the ASHM guidelines for OSCE success. Learn why routine asymptomatic screening is contraindicated and why Doxycycline (100mg BD for 7 days) must precede targeted treatment—either Azithromycin for susceptible strains or Moxifloxacin for resistant infections. We cover 14-day Moxifloxacin PID protocols, pregnancy safety traps, contact tracing for ongoing partners, and timing the mandatory 14–21 day Test of Cure. </p><p><br></p><p>#AMCClinicalExam #MycoplasmaGenitalium #OSCE #ResistanceGuidedTherapy #MoxifloxacinProtocol #MacrolideResistance #TestofCure #IMGAustralia #ASHMGuidelines #DoxycyclineSequentialTherapy</p><p><br></p><p><strong>Pro Tip:</strong> In your OSCE, never prescribe single-dose Azithromycin or immediate Moxifloxacin alone! High-scoring candidates demonstrate safety by explicitly using <strong>resistance-guided sequential therapy</strong>: initiating <strong>Doxycycline 100mg BD for 7 days</strong> to reduce bacterial load before stepping up to Azithromycin (if susceptible) or <strong>Moxifloxacin 400mg daily</strong> (if resistant). Highlight key exam traps: <strong>routine asymptomatic screening is NOT recommended</strong>, <strong>Moxifloxacin is Category B3 and avoided in pregnancy</strong> (requiring specialist input/Pristinamycin), and a <strong>Test of Cure (TOC) by NAAT must be delayed until 14–21 days post-treatment</strong> to avoid false positives!</p><p><br></p><p>🎧 <a href="https://apwix.com/100509">⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠</a> Episodes in <a href="https://apwix.com/100509">⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠<strong>Season 1</strong>⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠</a> (<em>150 clinical scenarios</em>) have been indexed by <strong>topic</strong>, <strong>patient group</strong>, <strong>discipline</strong>, <strong>setting</strong>, and more to support targeted learning. Use the filters to locate discussions relevant to your study or clinical training.</p>