Unmet needs in paediatric diabetes – the potential role of inhaled insulin

<p>Join host Dr. David Ahn and guest Dr. Michael Haller (Professor and Chief of Pediatric Endocrinology at the University of Florida and Chair of TrialNet) as they take a comprehensive review of the evidence base and remaining gaps for inhaled insulin use in pediatric and adolescent populations</p><p>In this final episode, we dive into:</p><ul><li><p><strong>Key Challenges in Pediatrics:</strong> Unmet needs in pediatric insulin therapy, including injection fatigue and tech-retention issues for active youth.</p></li><li><p><strong>The INHALE-1 Study:</strong> A deep dive into the randomized controlled trial data of 230 youth, highlighting efficacy, per-protocol non-inferiority, less weight gain, and superior treatment satisfaction among kids and parents.</p></li><li><p><strong>Safety Profile:</strong> Analyzing forced expiratory volume (FEV1) data showing an excellent safety signal with no differences in pulmonary function or severe hypoglycemic events.</p></li><li><p><strong>Practical Toolkit Use Cases:</strong> How the unique pharmacokinetic profile of inhaled insulin provides unmatched benefits for covering adrenaline-rush highs and avoiding hypoglycemia tail effects during sports and exercise.</p></li><li><p><strong>Dosing Guidelines:</strong> Overcoming the practical &quot;paradigm shift&quot; of converting injected units to inhaled units and managing dosing effectively.</p></li><li><p><strong>Future Horizons:</strong> Anticipating the &quot;INHALE FIRST&quot; study investigating early onboarding for newly diagnosed patients and introducing a new two-unit inhaled insulin cartridge.</p></li></ul><p><strong>About ATTD Diabetes Talks:</strong></p><p>A podcast series dedicated to providing healthcare professionals with the latest knowledge and best practices in diabetes management, supported by MannKind Corporation.</p><p>Find more resources on the ATTD Education Portal:<a href="https://unlok-education.com/attd/"> <u>https://unlok-education.com/attd/</u></a></p><p>Subscribe to the podcast for more updates on advancing diabetes care.</p><p>#DiabetesManagement #PediatricEndocrinology #InhaledInsulin #ATTD #DiabetesCare #MedicalPodcast #Type1Diabetes</p><p><strong>Chapters:</strong></p><p>00:00 Intro and Unique Challenges in Pediatric Diabetes Management</p><p>02:38 The INHALE-1 Study: Efficacy, Satisfaction, and Weight Findings</p><p>06:27 Safety Signals, Pulmonary Function, and Adherence Challenges</p><p>10:18 Practical Toolkit Use Cases: Managing Sports a