The Hidden Link Between Long COVID, Lyme Disease & Hypermobility with Dr. Ina Stephens (Ep 205)

Can a single infection permanently change your health, or does it simply reveal something that was already there?

In this episode, host Dr. Linda Bluestein, the Hypermobility MD, welcomes back Dr. Ina Stephens, Associate Director of the UVA Health EDS & Hypermobility Disorders Center, for an in-depth discussion about Long COVID, post-infectious syndromes, and their connection to Ehlers-Danlos syndromes (EDS), hypermobility spectrum disorders (HSD), and immune dysfunction.

Dr. Stephens explains why post-infectious illnesses are real and have been recognized for more than a century, tracing the pattern from the 1917 influenza pandemic and encephalitis lethargica to modern conditions including Long COVID, reactivated Epstein-Barr virus (EBV), Lyme disease, Babesia and other tick-borne infections, and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). She shares the detective work behind her Diagnostic Dilemma Clinic, how a comprehensive history and targeted evaluation uncover hidden diagnoses, and why so many patients with complex chronic illness also have hypermobility.

The conversation explores emerging research showing that people with hypermobility are approximately four times more likely to develop Long COVID, with an even greater risk in those with postural orthostatic tachycardia syndrome (POTS) and mast cell activation syndrome (MCAS). Dr. Stephens and Dr. Bluestein discuss the underlying biology, including immune dysregulation, autonomic nervous system dysfunction, vagus nerve dysfunction, mitochondrial dysfunction, and the ways connective tissue disorders may influence recovery after infection.

They also review evidence-informed treatment strategies, including supporting mitochondrial health with coenzyme Q10 (CoQ10), glutathione, and N-acetylcysteine (NAC); the role of low-dose naltrexone (LDN); optimizing iron and vitamin C status; when antiviral medications may be appropriate; intravenous immunoglobulin (IVIG); and glucagon-like peptide-1 (GLP-1) receptor agonists. Finally, they explain why gradually increasing muscle mass and strength may have a greater long-term impact than any single supplement and share practical strategies for supporting recovery and strengthening your regimen at the first sign of illness.

Whether you're living with EDS, HSD, Long COVID, POTS, MCAS, ME/CFS, Lyme disease, or another post-infectious condition, this episode offers practical, science-based insights into why these conditions overlap and what you ca