Low vitamin D and increased deaths

Lower levels of vitamin D, higher rates of deathUploaded 26-10-21Association of Serum 25-Hydroxyvitamin D Concentrations With All-Cause and Cause-Specific Mortality Among Adult Patients With Existing Cardiovascular Diseasehttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8496747/Observational study, non-interventionalBackgroundVitamin D, lower levels, common in patients with cardiovascular disease (CVD)Study of patients with existing CVD Prospectively examine the associations of serum 25-hydroxyvitamin D [25(OH)D] concentrations with,All-cause mortality and,cause-specific mortalityMethodsN = 37,079 patients with CVD from the UK Biobank studyFrom a prospective cohort of half a million, aged 40–69 yearshttps://www.ukbiobank.ac.ukCVDCoronary heart diseaseAtrial fibrillationHeart failureStrokeResultsAmong 37,079 patients with CVD at baseline, 57.5% were vitamin D deficientDeficient, 25[OH]D less than 50 nmol/L (less than 20ng/ml)Median follow-up of 11.7 yearsDeaths that occurred = 6,319 total 2,161 deaths from CVD2,230 deaths from cancer623 deaths from respiratory disease1,305 other-cause deathsNon-linear inverse associationsFor all-cause mortalityCancer mortalityRespiratory disease mortalityOther-cause mortalityThat is deaths went up as vitamin D levels went down(P-non-linearity less than 0.01)Approximately linear inverse associations for CVDThat is deaths went up as vitamin D levels went down(P-non-linearity = 0.074)Among CVD patients with vitamin D deficiencyFor every 10 nmol/L increment in serum 25(OH)D concentrations,There was an associated 12% reduced risk for all-cause mortalityThere was an associated 9% reduced risk for CVD mortality.In patients with vitamin D deficiencyPer 10 nmol/L increase in serum 25(OH)D levels,was associated with a lower risk of mortality from (aHR]; 95% CI)All-cause 0.88CVD 0.91Cancer 0.90Respiratory diseases 0.81Other causes 0.81Multivariable Cox regression modelsAge, sex, alcohol, BMI, GFR, education, ethnicity, household income, smoking status, healthy diet score, diabetes (and meds), HbA1c, duration of CVD, blood pressure (and meds), lipid profile (and meds), triglycerides, cholesterolConclusionAmong patients with existing CVD,increasing levels in serum 25(OH)D,were independently associated with a decreased risk of all-cause and cause-specific mortalityThese findings suggest that elevated serum 25(OH)D concentration benefits CVD patients with vitamin D deficiency.ThereforePatients with vitamin D deficiency may benefit more from a