HIT Journal Club: about the MAPLE-HCM trial

With Giovanni Benfari, University of Verona, Verona - Italy, Marija Brestovac, University Hospital Centre Zagreb, Zagreb - Croatia and Andreea Motoc, University Hospital (UZ) Brussels, Brussels - Belgium.

The second episode of the EACVI Journal Club podcast is dedicated to the MAPLE-HCM trial—comparing aficamten with metoprolol in patients with hypertrophic cardiomyopathy and LVOT obstruction—alongside a methodological discussion on how to approach sample size calculation in clinical trials.