329: Resiliency Radio with Dr. Jill: The Hidden Drivers of Brain Diseases with Dr. David Perlmutter

In this episode of Resiliency Radio with Dr. Jill, Dr. Jill Carnahan welcomes renowned neurologist and bestselling author Dr. David Perlmutter to explore the emerging science behind brain health, neuroinflammation, and cognitive resilience.

Drawing from his groundbreaking new book, Brain Defenders, Dr. Perlmutter explains how microglia—the brain's immune cells—play a central role in protecting or damaging the brain depending on our metabolism, lifestyle, and environment. Together they discuss why Alzheimer's and Parkinson's disease begin decades before symptoms appear, why inflammation and insulin resistance are major drivers of neurodegeneration, and what we can do today to protect lifelong brain health.

Whether you're concerned about memory loss, dementia prevention, or optimizing cognitive performance, this episode offers science-backed strategies to build a healthier, more resilient brain.

🔑 5 Key Discussions

① 🧠 Microglia: The Brain's Defenders

⇨ Microglia protect neurons, maintain synapses, and defend the brain from injury and infection.

⇨ Chronic inflammation can transform these protective cells into drivers of Alzheimer's, Parkinson's, and cognitive decline.

② 🔥 Immunometabolism & Brain Health

⇨ Blood sugar, insulin resistance, inflammation, and metabolism directly influence how microglia function.

⇨ Improving metabolic health helps create a brain environment that supports healing rather than degeneration.

③ 🥗 Lifestyle Shapes Brain Destiny

⇨ Nutrition, exercise, sleep, stress management, and social connection have profound effects on brain health.