How Estrogen Clearance Affects Breast Cancer & Menopause Risk with David & John | Mara Labs

<p>Sarah introduces an Evolving Wellness episode on estrogen clearance, perimenopause/menopause, and why estrogen therapy isn’t one-size-fits-all, then interviews John and David from Mera Labs, whose work on sulforaphane began after both of their wives faced breast cancer. They explain how sulforaphane activates NRF2, supporting phase 2/3 detoxification, antioxidant responses, mitochondrial function, and mitophagy, and discuss circadian oscillations of NRF2. Sarah shares her experience of heavy bleeding, PMS, and low ferritin improving after several cycles on their product, with benefits also noted for her autistic teen. The guests differentiate stabilized sulforaphane from glucoraphanin products, describe synergy from added PEITC, discuss dosing timing, toxins/microplastics and endocrine disruptors, DIM questions, stress and vagal regulation, and note a rare microbiome-driven estrogen recycling condition linked to galactorrhea</p><p><br></p><p>— </p><p>Connect with John and David</p><p><a href="https://mara-labs.com/">https://mara-labs.com/</a> </p><p><a href="https://www.instagram.com/themaralabs/">https://www.instagram.com/themaralabs/</a> </p><p><br></p><p>For the next week, Evolving Wellness loyal listeners can get an exclusive 25% off all Mara Labs products when you go to <a href="http://www.mara-labs.com/SARAHK">www.mara-labs.com/SARAHK</a> and use code SARAHK at checkout. After one week, the code will return to the standard 15% off.</p><p><br></p><p>_________</p><p>Timestamp:</p><p>00:00 Microbiome Estrogen Recycling</p><p>00:44 Why This Episode Matters</p><p>03:14 Podcast Intro and Disclaimers</p><p>04:27 Meet the Mera Labs Founders</p><p>10:26 Sarah’s Estrogen Clearance Story</p><p>14:57 Sulforaphane Science and Nrf2</p><p>31:30 DIM vs Sulforaphane Debate</p><p>35:09 Minimize Menopause Formula</p><p>37:54 Estrogen Therapy Prep</p><p>41:58 Stress Epigenetics Reset</p><p>44:38 Vagus Nerve Tools</p><p>49:42 Sulforaphane Dosing Guide</p><p>52:44 Toxins Microplastics Foods</p><p>01:05:29 NRF2 Safety Wrap Up</p><p>——— </p><p>This video is not medical advice &amp; as a supporter to you and your health journey - I encourage you to monitor your labs and work with a professional!</p><p>________________________________________</p><p>Get all my free guides and product recommendations to get started on your journey!</p><p>https://www.sarahkleinerwellness.com/all-free-resources</p><p><br></p><p>Check out all my courses to understand how to improve your mitocho