#257 Dr. Dale Bredesen — Can Alzheimer's Be Prevented? New Trial Results & Brain Biomarkers

<p>Ready to unlock your brain’s superpower? Download my free 5-Minute Brain Blueprint to boost mental clarity, sharpen focus, and support lifelong cognitive vitality → <a rel="noopener noreferrer nofollow" href="https://longevity-and-lifestyle.com/BRAIN" target="_blank">https://longevity-and-lifestyle.com/BRAIN</a><br /><br />This episode is brought to you by:<br /><br />BioLongevity Labs, science-led supplements supporting mitochondrial function, gut resilience, recovery, and eye health, with transparent ingredients and third-party testing: <a rel="noopener noreferrer nofollow" href="https://BioLongevitySupplements.com" target="_blank">https://BioLongevitySupplements.com</a><br /><br />Get 20% off with code CLAUDIA20.<br /><br />What if cognitive decline is not as inevitable as we have been told?</p><p>In this episode of the Longevity &amp; Lifestyle Podcast, I welcome back Dr. Dale Bredesen, internationally recognized neurologist, bestselling author, and pioneer in the prevention and reversal of cognitive decline.<br /></p><p>Dr. Bredesen shares the findings from his latest randomized controlled trial, in which 90% of participants receiving a precision medicine protocol improved. We explore why Alzheimer’s may begin decades before symptoms appear, the biomarkers that can help identify risk earlier, and the lifestyle and medical factors that may influence cognitive health.<br /></p><p>We also discuss the role of sleep, insulin resistance, inflammation, toxins, ketones, peptides, stem cells, GLP-1 medications, psychedelics, and neuroplasticity.<br /></p><p>This conversation offers an important message: the earlier we understand what is driving cognitive decline, the greater the opportunity to act.<br /></p><p>In this episode, you’ll learn:</p><p>• Why Alzheimer’s may begin decades before symptoms<br />• What Dr. Bredesen’s latest trial revealed<br />• The stages from prevention to dementia<br />• Blood biomarkers linked to early decline<br />• Insulin resistance, ketones, and brain energy<br />• Sleep apnea and long-term brain health<br />• Why there is no single cure<br /></p><p>TIMESTAMPS</p><p>00:00 Introduction<br />03:37 The Alzheimer’s trial where 90% improved<br />06:35 What drives cognitive decline<br />12:01 Why Alzheimer’s is no longer viewed as hopeless<br />16:08 The four stages of cognitive decline<br />18:22 Blood tests that may reveal risk earlier<br />22:22 The key drivers of Alzheimer’s<br />23:36 The seven foundations of brain health<br />25:53 Sleep targets for cognitive longevity<br />28:27 GLP-1s and Alzheimer’s risk<br />31:35 Peptides for brain health<br />35:59 Stem cells, exosomes, and regenerative medicine<br />39:32 Is there hope at every stage?<br />40:45 Inside the randomized clinical trial<br />46:18 Psychedelics and neuroplasticity<br />52:31 Dr. Bredesen’s final message<br /></p><p>CONNECT WITH DR. DALE BREDESEN</p><p>Website: <a rel="noopener noreferrer nofollow" href="https://www.drbredesen.com" target="_blank">https://www.drbredesen.com</a><br />Free cognitive assessment: <a rel="noopener noreferrer nofollow" href="https://www.mycqtest.com" target="_blank">https://www.mycqtest.com</a><br />Brain biomarker testing: <a rel="noopener noreferrer nofollow" href="https://www.getabrainscan.com" target="_blank">https://www.getabrainscan.com</a><br /></p><p>CONNECT WITH CLAUDIA</p><p>Website: <a rel="noopener noreferrer nofollow" href="https://longevity-and-lifestyle.com" target="_blank">https://longevity-and-lifestyle.com</a><br />Instagram: <a rel="noopener noreferrer nofollow" href="https://www.instagram.com/longevityandlifestyle" target="_blank">https://www.instagram.com/longevityandlifestyle</a><br />YouTube: <a rel="noopener noreferrer nofollow" href="https://www.youtube.com/@LongevityandLifestyle" target="_blank">https://www.youtube.com/@LongevityandLifestyle</a><br /></p><p>#DaleBredesen #Alzheimers #BrainHealth #CognitiveDecline #DementiaPrevention #Longevity #PrecisionMedicine #Neuroplastici