How Cells Sense and Integrate Metabolic Signals

How does exercise stimulate glucose uptake in muscle and what can this teach us about treating type 2 diabetes?

Prof. Kei Sakamoto, recipient of the 12th EASD - Novo Nordisk Foundation Prize for Excellence, speaks to EASD TV host Vivienne Parry about the molecular mechanisms connecting exercise, energy regulation and insulin signalling. He explains the role of LKB1 and AMPK, explores the potential and limitations of targeting these pathways therapeutically.

The conversation also explores the complexity of diabetes, the importance of targeting specific molecular pathways and tissues and why fundamental research is essential for developing future treatments.