The Estrogen Effect Nobody Talks About | Kiran Krishnan

Cardiovascular health and longevity are deeply influenced by aging, perimenopause, and systemic changes that extend far beyond cholesterol markers alone.

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In this episode of New Frontiers in Functional Medicine, Dr. Kara Fitzgerald sits down with Kiran Krishnan to explore the biology of vascular aging, endothelial dysfunction, and metabolic changes that emerge in midlife and beyond. As estrogen declines during perimenopause, patients often experience shifts in lipid metabolism, weight regulation, and overall metabolic resilience—driving increased cardiovascular risk.

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This conversation dives into the critical role of the endothelial glycocalyx, nitric oxide signaling, and the gut microbiome in maintaining vascular integrity and systemic health. Dr. Fitzgerald and Kiran connect the dots between gut health, cardiovascular disease, joint degeneration, and systemic inflammation, offering a systems biology approach that is highly relevant for functional medicine practitioners.

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You’ll also hear how targeted interventions—specifically Arterosil, Vascanox, and Cartigenix—can be used synergistically to support endothelial health, nitric oxide production, microbial balance, and joint integrity.

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Topics covered include:

- Endothelial glycocalyx dysfunction and cardiovascular risk

- Nitric oxide signaling and vascular health

- Perimenopause, estrogen decline, and metabolic changes