Alexander Disease Research Update – Episode #32: 1) GFAP variants and oxidative stress, and 2) GFAP variants and lysosomes

Send us Fan Mail Albee Messing, Dolores Pérez-Sala, and Natasha Snider discuss the following recent publications: Alexander disease mutations differentially sensitize glial fibrillary acidic protein (GFAP) to posttranslational modifications and network disruption by oxidants. Redox Biology 92:104103 (2026) Lysosomal function, resistance to oxidative stress and repair are compromised by expression of the Alexander dise...