Cannabis and Brain Aging: Can weed keep your brain young?

Can weed protect your brain as you get older? We unpack a study linking lifetime cannabis use to larger brain volumes and better cognitive test scores in older adults—and investigate how those findings became headlines urging readers to “pass the pot to grandma.” Along the way, we explore collapsing categorical variables, confounding, clinically versus statistically significant results, multiple testing, and how a press release subtly changed a story. We also meet permanently stoned mice, learn about Carl Sagan’s surprising connection to cannabis research, and discover how a single missing word can change the entire meaning of a study.

Statistical topics

Categorical variablesConfoundingEffect sizeFalse discovery rateHealthy volunteer biasMeasurement errorMultiple testingObservational studiesRecoding variablesScience communicationStatistical vs practical significance

Methodologic Morals

“Always follow the chain from data to result to conclusions and pay attention to the words along the way.”“Huge samples can give tiny differences delusions of grandeur.”

References

Guha A, Fu Z, Calhoun V, Hutchison KE. Lifetime Cannabis Use Is Associated With Brain Volume and Cognitive Function in Middle-Aged and Older Adults. J Stud Alcohol Drugs. 2026;87(4):739-751. doi:10.15288/jsad.25-00346Press Release: https://news.cuanschutz.edu/news-stories/study-finds-cannabis-usage-in-middle-aged-and-older-adults-associated-with-larger-brain-volume-better-cognitive-functionBilkei-Gorzo A, Albayram O, Draffehn A, et al. A chronic low dose of Δ9-tetrahydrocannabinol (THC) restores cognitive function in old mice. Nat Med. 2017;23(6):782-787. doi:10.1038/nm.4311NY Post: https://nypost.com/2026/02/07/health/cannabis-may-benefit-aging-brains-study-finds/David Grinspoon: https://www.nytimes.com/2020/07/02/science/lester-grinspoon-dead.html?unlocked_article_code=1.7lA.CyS1.neeqGGNgx8g1&smid=url-share

Kristin and Regina’s online courses:

Demystifying Data: A Modern Approach to Statistical Understanding

Clinical Trials: Design, Strategy, and Analysis

Medical Statistics Certificate Program

Writing in the Sciences