SE5:E2: The Macrocyclic Mullet

<p>What happens when the textbook SAR playbook stops working? On this episode of <em>Pharm to Table</em>, Rob Garbaccio joins Dani and LC to share the discovery story behind enlicitide (MK-0616), a journey filled with unusual SAR, creative problem-solving, and plenty of chemistry twists along the way. From issue-driven drug design to non-canonical amino acids and modular synthesis strategies, this conversation offers a behind-the-scenes look at how real medicines are discovered. If you're training as a chemist today, this is a story you won't want to miss.</p><p><br /></p><p>If you enjoyed this chapter of the enlicitide story, stay tuned—we've got plenty more peptide chemistry, process development adventures, and behind-the-scenes drug discovery stories coming your way this season.</p><p><br /></p><p><strong>Read some of the papers we discussed today:</strong></p><p><em>Discovery Process of Enlicitide, a Highly Engineered Macrocyclic Peptide Therapeutic, through Issue-Driven Fragment-Based Synthetic Assembly and SAR - </em><a href="https://pubs.acs.org/doi/10.1021/acs.jmedchem.6c00463" target="_blank" rel="ugc noopener noreferrer">⁠<em>J. Med. Chem.</em>⁠</a></p><p>Follow the Pharm to Table podcast on X - ⁠⁠⁠⁠@PharmtoTablePod</p><p>⁠⁠⁠⁠Visit our website at <a href="https://podcasters.spotify.com/pod/show/pharm-to-table" target="_blank" rel="ugc noopener noreferrer">⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://podcasters.spotify.com/pod/show/pharm-to-table⁠⁠⁠⁠⁠⁠</a> </p><p><br /></p>