DOE, The Right Thing (with Keara Sutherland)

<p>If efficiency is the name of the game in process development, then Design of Experiments (DOE) is the playbook you didn’t know you needed. </p><p>But how do you actually apply it in the messy, variable world of viral vector production? That’s exactly what we dig into in this episode. </p><p>Keara Sutherland takes us through her journey from simple drug pairing experiments to complex, high-dimensional DOE campaigns that optimize biological processes in ways that feel almost magical – but are grounded in solid strategy.</p><p><br></p><p><strong>Conversation highlights:</strong></p><p><strong>05:24 </strong>- Keara’s first exposure to DOE and transitioning from drug synergy studies to complex process optimization</p><p><strong>12:17</strong> - The addictive efficiency of DOE: maximizing data points while minimizing time</p><p><strong>17:26</strong> - DOE as a tool for biological flexibility: managing multiple outputs and future-proofing processes</p><p><strong>31:31</strong> - Real-world challenges: balancing experimental ideal with practical constraints, including automation and scalability</p>