
← The Next Experiment12 Jan · 42 min
Choose Your Fighter: Bayesian vs DOE (with Owen Jonathan)
<p>This time, Markus and Phil sat down with Owen Jonathan, who brings a refreshingly open and grounded perspective on learning – and teaching – DOE in real biological systems.</p><p>What makes Owen’s story so compelling is how honestly he talks about coming into DOE with an open mind, realising what he <em>hadn’t</em> been taught, and then discovering how powerful the methodology becomes when biology is too complex for intuition alone.</p><p>A few standout quotes:</p><p>🔹 “I didn’t realize until later that I’d never actually been taught DOE.” 🔹 "Progress isn’t about doing more — it’s about asking the right questions first." 🔹 “Biology needs abstraction or it becomes impossible to model.”</p><p>If you’re interested in practical experimentation, ML-enabled workflows, or how real scientists bring DOE into messy biology, this one’s packed with insight.</p>