Methylene Blue for Brain Fog, Anxiety and Low Energy | Dr. Scott Sherr, MD

Methylene blue is one of the most talked-about tools in biohacking for mitochondrial function, brain fog, and energy—and the nuance is in dosing, quality, and context. In this episode, Dr. Scott Sherr explains how chronic stress and hormone shifts can trap women in a “wired but tired” state, why HRV drops when your nervous system can’t recover, and how sleep architecture, minerals, and mitochondrial support may help restore resilience. You’ll also learn the red flags of low-quality methylene blue, why low-dose and high-dose effects are different, and how to think about redox balance without making your stress physiology worse.

KEY TOPICS

Methylene blue benefits dosing and quality concerns

Mitochondrial dysfunction behind brain fog fatigue and anxiety

HRV and nervous system resilience in midlife women

Sleep architecture REM sleep and why waking at night happens

Minerals electrolytes cortisol and the wired but tired stress loop

TIMESTAMPS

[00:00] Metabolic health crisis and why mitochondrial dysfunction is so common

[01:06] Show introduction and what this episode will help you fix

[01:37] Scott Sherr’s integrative path and Health Optimization Medicine approach

[03:57] The Sympathetic Spiral of Doom and what it looks like in real life