Episode 84: MDMA: Why Does Toxicity Differ Between People?

<p>This week on The Tox Lab, we’re discussing MDMA, examining its pharmacology, toxicity, and the factors that influence individual susceptibility to harm.</p><p>We begin by exploring how MDMA works, focusing on its effects on serotonin release, reuptake, and signalling, and the pharmacological mechanisms responsible for its desired effects and adverse reactions.</p><p>We then examine a case of severe MDMA toxicity resulting in hyperthermia and multi-organ failure, discussing the clinical features, management, and the toxicological mechanisms underlying these life-threatening complications.</p><p>Finally, we turn to the role of the polymorphic enzyme CYP2D6 in MDMA metabolism, examining how genetic variation and MDMA-induced inhibition of CYP2D6 can influence drug concentrations, toxicity, and the risks associated with repeat dosing and drug interactions.</p><p>Join us as we examine the pharmacology, clinical toxicology, and pharmacogenetics of MDMA, and consider what these findings mean for understanding both its desired effects and its potential harms.</p><p><br></p><p>Hope you enjoy!</p><p><br></p><p>Links to the papers we discussed:</p><p><a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC11470468/pdf/main.pdf" target="_blank"><u>https://pmc.ncbi.nlm.nih.gov/articles/PMC11470468/pdf/main.pdf</u></a></p><p><a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC3495276/pdf/fgene-03-00235.pdf" target="_blank"><u>https://pmc.ncbi.nlm.nih.gov/articles/PMC3495276/pdf/fgene-03-00235.pdf</u></a></p><p><a href="https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/dta.2605" target="_blank">https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/dta.2605</a> </p><p><br></p><p>Disclaimer: All opinions are our own.</p><p>Find us on instagram: @the_tox_lab</p><p>Email us here: <a href="mailto:thetoxlab@gmail.com" target="_blank">thetoxlab@gmail.com</a></p><p>Check out our new website: <a href="https://thetoxlab.co.uk/" target="_blank">https://thetoxlab.co.uk/</a> </p><p>Support us here: <a href="https://buymeacoffee.com/thetoxlab" target="_blank">https://buymeacoffee.com/thetoxlab</a></p><p><br></p>