PCOS to PMOS: Courtney's Story, Insulin Resistance, Autophagy Genetics, Hormone Conversion, and Fertility

In this episode, Dr. Stewart sits down with his daughter Courtney to break down PCOS — now being renamed PMOS (Polyendocrine Metabolic Ovarian Syndrome). Courtney shares her own journey with PCOS since age 13, and Dr. Stewart explains what's really happening at the cellular and genetic level behind the diagnosis. They dig into:

Why PCOS was renamed PMOS

How insulin resistance and autophagy genes drive ovarian dysfunction

Why testosterone becomes "dominant" — and why it's a conversion problem, not overproduction

Fertility, pregnancy, and gestational diabetes risks tied to insulin resistance

Why rates of PCOS/PMOS appear to be rising, including the role of environmental endocrine disruptors

Dr. Stewart also walks through treatment approaches, from supplement-based options like D-chiro-inositol and berberine, to GLP-1/GIP therapies like tirzepatide, including how it differs from semaglutide, proper dosing and maintenance, and why continuous glucose monitoring often gives a clearer picture than a single lab draw. He shares how these approaches are used to support:

Irregular, painful, or absent menstrual cycles

Weight gain that doesn't respond to diet and exercise

Chronic fatigue and brain fog

Fertility struggles and pregnancy risk

Acne and excess hair growth linked to testosterone dominance