Episode 222: Local Anesthetic Systemic Toxicity (LAST)

We discuss this ominous complication of providing local anesthesia.

Hosts:

Elaine Jonas, MD

Brian Gilberti, MD

https://media.blubrry.com/coreem/content.blubrry.com/coreem/LAST.mp3

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Tags: Critical Care, Toxicology

Show Notes

I. Pathophysiology & Mechanisms

Definition: Systemic toxicity secondary to local anesthetic (LA) via accidental intravascular injection or excessive systemic absorption.

Threshold: Occurs when plasma concentration exceeds the safety threshold for cardiac and neural tissue.