Saphris Made Easy: Why Choose Asenapine Over Other Antipsychotics?

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What about Saphris (asenapine)?

In this episode of Pearls & Prep, we break down one of the more overlooked second-generation antipsychotics and explore where asenapine may fit in the treatment of bipolar I disorder, acute mania, mixed episodes, and schizophrenia.

We’ll cover why Saphris is given sublingually, what makes its receptor profile unusual, and how its strong dopamine D2, serotonin 5-HT2A/5-HT2C, histamine H1, and adrenergic activity translates into clinical practice.

We’ll also tackle an important bipolar pearl: Saphris can be used for bipolar I maintenance even though it is not an established treatment for acute bipolar depression.

You'll learn:

• Who may be a good candidate for Saphris

• When you might choose asenapine for acute mania or mixed symptoms

• Why Saphris must dissolve under the tongue