Why You Feel Older Than Your Labs Say You Are with Dr. Will Cole | E224

<p>🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr.</p><p>Perlmutter’s newsletter at: www.drperlmutter.com. ✉ 🌱 Thank you to our sponsors:</p><p>EVY - https://www.optoceutics.com/perlmutter and the code perlmutter26 will be auto-applied to your order to get 10% off &amp; free shipping (90 days risk-free).</p><p>3x4 Genetics - https://3x4genetics.com/DrPerlmutter for a special offer when you sign up to decode your genetics and get personalized, science-backed health recommendations.</p><p>====</p><p>Dr. Perlmutter’s groundbreaking new book, Brain Defenders, is now available! Discover how to protect your brain and future health - grab your copy today at https:/www.braindefenders.com.</p><p>====</p><p>Why do some people feel exhausted, mentally foggy, metabolically unwell, or simply older than they should even when their routine laboratory results are considered “normal”?</p><p>That question is at the heart of this episode of <em>The Empowering Neurologist</em>, featuring functional medicine practitioner Dr. Will Cole, coauthor with Dr. Josh Axe of <em>Heal Your Cells: Reversing the Irreversible</em>.</p><p>Dr. Cole and Dr. Perlmutter explore the idea that long before disease becomes obvious, dysfunction may already be developing at the cellular level. This concept takes on particular importance when we consider the brain, which accounts for only about 2% of body weight but consumes roughly 20% of the body's energy at rest.</p><p>The conversation examines how seemingly separate factors including metabolic dysfunction, chronic inflammation, poor sleep, environmental exposures, physical inactivity, and prolonged psychological stress can converge on the same cellular systems and ultimately influence brain health.</p><p>00:00 — Why Your Cells May Be Aging Before You Feel It</p><p>03:44 — Meet Dr. Will Cole</p><p>04:50 — What Is Cellular Dysfunction?</p><p>09:25 — Why Healthy People Can Still Develop Disease10:32 — The Environmental Factors Affecting Cellular Health</p><p>15:47 — Why Mitochondria Are Central to Health</p><p>16:37 — How Mitochondrial Dysfunction Drives Inflammation</p><p>19:57 — How Much of Aging Can We Actually Change?</p><p>20:47 — The Connection Between Mitochondria and Insulin Resistance</p><p>25:43 — Mitochondria, Microglia, and Brain Inflammation</p><p>29:28 — Why There Is No One-Size-Fits-All Diet</p><p>32:03 — Training Your Cells to Become More Resilient</p><p>32:46 — What Are “Adversity Mimetics”?</p