Beyond Small Molecules—Allometric Scaling for Biologics and Engineered mAbs (Ep. 58)

<p>Today’s episode is about allometric scaling with therapeutic antibodies. I discuss differences from small molecules, how to handle antibodies with engineered Fc regions (e.g. YTE or LS), and using allometry to extrapolate from adults to pediatrics for these antibodies. </p><p><br></p><p>Links discussed in the show:</p><ul><li>Haray and Tachibana’s <a href="https://link.springer.com/article/10.1007/s40259-022-00566-2" target="_blank" rel="noopener noreferer">article on allometric exponents for monoclonal antibodies</a> </li><li>Exponents for standard antibodies: CL = 0.8, Q = 0.75, Vc = 1/.0, Vp = 0.95</li><li>Exponents for modified antibodies: CL = 0.55, Q = 6, Vc = 0.95, Vp = 0.95</li><li>You can <a href="https://go.teuschersolutions.com/linkedin" target="_blank" rel="noopener noreferer">connect with me on LinkedIn and send me a message</a> </li><li><a href="https://go.teuschersolutions.com/contact" target="_blank" rel="noopener noreferer">Send me a message</a> </li><li><a href="https://go.teuschersolutions.com/newsletter" target="_blank" rel="noopener noreferer">Sign up for my newsletter</a> </li></ul><p><br></p><p>Copyright Teuscher Solutions LLC</p><p>All Rights Reserved</p><p><br></p>