Some permanent long covid

Link to free download of John’s 2 textbooks.http://159.69.48.3/ (you may need to cut and paste this link into a brouser)Uploaded 04-08-22Profiling post-COVID syndrome across different variants of SARS-CoV-2https://www.medrxiv.org/content/10.1101/2022.07.28.22278159v1Across all variantsCentral neurological cluster of symptomsCardiorespiratory cluster of symptomsDebilitating multi-organ systemic inflammatory symptomsCentral neurological cluster of symptomsAnosmia / dysosmiaFatigueBrain-fogDepressionDeliriumHeadache(Largest cluster in both alpha and delta variants, and the second largest for the wild-type variant)Consistent UK Biobank studySARS-CoV-2 is associated with changes in brain structure in UK Biobankhttps://www.nature.com/articles/s41586-022-04569-5?feature%5Bconsent-app%5D=1&optanonConsent=15Reduction in grey matter thicknessTissue damage in primary olfactory cortexReduction in global brain size Cardiorespiratory cluster of symptoms(Largest cluster in the wild-type period)Symptoms may reflect lung damageDyspnoeaChest painFatiguePalpitationsConsistent study from MedicineClinical characteristics and outcomes of post-COVID-19 pulmonary fibrosishttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8772621/Post-COVID-19 pulmonary fibrosis is a severe complication that leads to permanent lung damage or death.Debilitating multi-organ symptoms(Present in all variants)Systemic/inflammatoryAbdominal symptomsMyalgias (muscle pain)Vaccination and long covidwe did not observe evidence of qualitatively different symptom clustering in vaccinated vs. unvaccinated individuals, with either alpha or delta variants. BackgroundIt is now evident that post-COVID syndrome presents with heterogeneous profiles,need characterisation to enable personalised careMethodsProspective longitudinal cohort studyN = 336,652 subjects(Covid Symptom Study)Tested positiveLong-COVID = lasting longer than 28 daysN = 1,459 with post-COVID syndrome (more than 12 weeks of symptoms)One in 230 symptomatic, test confirmed casesClustering analysis, to identify distinct symptom profilesAcrossVariants of SARS-CoV-2Vaccination status at the time of infectionClusters were characterisedSymptom prevalenceDurationDemographyPrior conditions (comorbidities)FindingsWe identified distinct profiles of symptoms for post-COVID syndromeWild-type variantFour endotypes identifiedAlpha variantSeven endotypesDelta variantFive endotypes in vaccinated subjectsEndotypea subtype of a disease condition, defined by a distinct patho