⚖️ GZMK vs GZMB: The T-Cell Balance That May Define Healthy Aging

🧬 Can your T cells reveal how well you're aging?

A remarkable Immunity study integrated 2,609 people and >12 million cells across 8 cohorts. Researchers identified divergent CD8+ effector-memory T-cell trajectories: a higher GZMK+/GZMB+ ratio tracked healthier aging, while GZMB+ cells were linked to inflammation, poorer health and mortality.

Single-cell analyses of global cohorts outline determinants of immune aging and link the ratio of GZMK+ to GZMB+ Tem cells to health trajectories.pdf

💡 The intriguing possibility: biological aging may be captured not simply by how many years we've lived—but by the balance of our immune cells.

🎙️ Dr RR Baliga's Podkast for the Kurious Doc.