AI-Designed Viruses

This week we talk about Evo 2, bacteriophages, and antibiotics.

We also discuss AI models, medical innovations, and the Red Army.

Recommended Book: The Design of Everyday Things by Donald A. Norman

Transcript

A bacteriophage, sometimes just called a phage, is a type of virus that only infects bacteria. “Phage” means to devour, and that’s what bacteriophages do—they infect and replicate within bacteria that they target, injecting their own genome into that target’s cytoplasm, which are all the materials contained within the bacteria’s cell membrane.

Phages are super-abundant, by some measures more abundant than every living organism, including bacteria, on earth, combined. And they’re interesting in that they range from incredibly simple to quite complex, and have at times been used as alternatives to antibiotics, because they attack and feed on bacteria.

The use of phages to counter bacterial infections was all but abandoned in the mid-20th century when antibiotics were discovered and commercialized, their production industrialized and the substances themselves proving a lot easier to mass-produce, and a lot more predictable in their utility than phages. Phages were kinda sorta almost understood, but we didn’t really get what they were doing or why, so their application often felt more like folk remedies than real-deal science, despite the actual science underlying the practice.

Also, phages were primarily used as antibiotic treatments by the Red Army, the Soviet Union’s military. So throughout the West, which was rapidly scaling its production of antibiotic treatments, the use of bacteriophages was associated with Stalinist communism, and so the Red-scare, the demonization of anything associated with the Soviet Union, was partially responsible for the shelving of this approach and this realm of research, at least for a while.

Much of that existing research was also done in the Soviet Union, and the published documents were thus published in Russian or Georgian languages. And because much of the rest of the scientific publishing world was reorienting around English at this time, that meant these published works were often either ignored or unintelligible to the rest of the scientific community.

As with much of our microbiota, the invisibly small viruses, bacteria, archaea, and so on that make up the human microbiome, we have a general sense of how bacteriophages interact with some of what makes us, us, but only a general sense. We know that healthy individ