Can Psychedelics Make You Better at Non-Monogamy?

Can psychedelics actually make you better at non-monogamy?

Jealousy. Fear. Defensiveness. Insecurity. The urge to control what your partner does so you don’t have to feel something uncomfortable.

These are some of the hardest parts of opening a relationship, and in this episode, Scott sits down with Dr. Chandra Khalifian and Dr. Kayla Knopp, co-founders of Enamory, to explore whether psychedelic-assisted therapy can help us respond to those challenges differently.

Chandra and Kayla work at the intersection of couples therapy, expansive relationships, and psychedelic-assisted psychotherapy. Together, they explore how substances like MDMA and ketamine may temporarily reduce defensiveness, increase cognitive flexibility, deepen empathy, and make it easier to see a conflict through your partner’s eyes.

And that creates a fascinating possibility for non-monogamy: What if the goal isn’t to eliminate jealousy, fear, or insecurity?

What if the goal is to become better at experiencing those emotions without immediately trying to restrict someone else’s freedom?

Scott, Chandra, and Kayla discuss:

• How to talk to your partner about opening your relationship

• Why being terrified to raise the subject may reveal a deeper issue

• What happens in the brain when MDMA reduces fight-or-flight responses

• Why psychedelics may make us less defensive during difficult conversations

• How non-monogamy can expose our instinct to control what makes us uncomfortable