What drives the fibrotic disease progression in IPF/PPF?

In this APAPP FAQ, Jessica Glennie, CNP, discusses what drives fibrotic disease progression in idiopathic pulmonary fibrosis (IPF) and progressive pulmonary fibrosis (PPF). Jessica explains how repeated microinjuries to the alveolar epithelial cells can disrupt the lungs’ natural repair process, triggering the release of profibrotic growth factors and cytokines. These signals recruit fibroblasts, promote their transformation into myofibroblasts, and lead to excessive collagen deposition and e...