The Hidden Stress Response That's Hijacking Your Brain with Dr. Scott Sherr | E222

<p>🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱 Thank you to our sponsors: EVY - https://www.optoceutics.com/perlmutter and the code perlmutter26 will be auto-applied to your order to get $200 off &amp; free shipping (90 days risk-free). </p><p>3X4 Genetics - https://3X4genetics.com/DrPerlmutter for a special offer when you sign up to decode your genetics and get personalized, science-backed health recommendations.</p><p>====</p><p>Dr. Perlmutter’s groundbreaking new book, Brain Defenders, is now available for pre-order. Discover how to protect your brain and future health - reserve your copy today at https://www.braindefenders.com.</p><p> ====</p><p>We dig into why 94% of US adults have some metabolic dysfunction, how the body can enter a full stress response with no psychological trigger, why GABA supplements work for some people and not others, and what that reveals about gut health. </p><p>00:00 - Introduction</p><p>00:06 - The Sympathetic Spiral of Doom</p><p>01:04 - Brain Defenders: A New Way to Think About Brain Health</p><p>03:25 - Welcoming Dr. Scott Sherr</p><p>04:42 - Why Stress Has a Metabolic Component Most People Overlook</p><p>06:00 - 94% of Adults Have Metabolic Dysfunction</p><p>07:00 - Mitochondria 101: Why Some Cells Have Thousands and One Has None</p><p>07:58 - Insulin Resistance</p><p>08:50 - Toxins, Infections, and Other Roads to Metabolic Breakdown</p><p>09:28 - How Mitochondrial Stress Triggers a Stress Hormone Spiral</p><p>10:47 - The Cell Danger Response</p><p>13:49 - Brain Defenders: How Mitochondrial Dysfunction Polarizes Microglia</p><p>15:22 - Stress Without a Stressor: How Metabolism Alone Can Trigger Fight-or-Flight</p><p>16:01 - Straws on the Camel&#39;s Back: Situational vs. Metabolic Stress</p><p>17:01 - GABA, the Brain&#39;s Brake Pedal, and Why Oral GABA Doesn&#39;t Work</p><p>18:20 - 40 Hz Light Therapy and Cognitive Decline21:00 - GABA vs. Glutamate: The Balance Behind 80% of Brain Signaling</p><p>22:17 - The Depression-Serotonin Myth and the Real Role of GABA</p><p>23:04 - Why GABA Supplements Stop Working Once You Heal Your Gut</p><p>24:18 - Kava, CBD, and the Amanita Mushroom Compound That Calms the Brain</p><p>25:06 - How to Know You&#39;re in Sympathetic Overdrive Without a Wearable</p><p>26:16 - 70,000 vs. 120,000 Thoughts a Day: The Stress Math</p><p>27:33 - Recovery Is the Real Marker of Resilience</p><p>28:05 - H