The Forgotten Sense: How Smell Impacts Brain Health, Mood, and Aging Well

What if one of the most overlooked indicators of brain health is something we rarely think about—our sense of smell?

In this Living to 100 Club episode, Dr. Joe Casciani speaks with Jonathan Askholm about the emerging science of olfactory health. We spotlight its surprising connection to cognitive function, mood, and overall well-being. While vision and hearing loss receive widespread attention, smell loss often goes unnoticed—even as it may signal deeper neurological changes.

Jonathan shares insights from recent research showing how olfactory training—simple, daily exposure to specific scents—has surprising benefits. It may help strengthen neural pathways, support memory, and even reduce depressive symptoms. The conversation explores why smell declines with age. Also discussed is how it affects quality of life, and why this “forgotten sense” deserves a more prominent role in healthy aging strategies.

Listeners will come away with a new appreciation for the role of smell in brain health. And listeners gain practical ideas for incorporating olfactory awareness into daily life.

🔑Key Topics Covered

Why smell loss is often overlooked compared to hearing and vision

The connection between olfactory function, the brain, and emotional health

Research linking smell loss to cognitive decline and depressive symptoms

How olfactory training works (simple daily scent exercises)

The role of neuroplasticity in maintaining and improving smell function

Practical applications for older adults and those concerned about brain health

Why smell may be an early indicator of neurological change