The Broken Pipeline: Rethinking Drug Development

Kayla Ellsworth explores why nearly 90% of drug candidates fail and how New Approach Methodologies (NAMs) are transforming drug development. She explains how technologies like AI, omics, advanced in vitro models, and microphysiological systems better replicate human biology, improving research while reducing reliance on animal testing. The conversation also highlights the importance of innovation, women in leadership, and emerging technologies such as brain-on-a-chip that are shaping the future of healthcare.

Chapters:

00:00 The Drug Development Crisis

09:08 Introducing New Approach Methodologies (NAMS)

17:53 Exploring NAMS: In Silico to Microphysiological Systems

25:19 Dynamic Microphysiological Systems

26:39 Evidence of Effectiveness in Drug Development

28:48 Speeding Up Drug Development Processes

30:42 Integrating New Approaches in Drug Development

32:17 The Future of Animal Testing

34:21 Women in Leadership and Industry

39:43 Role of Speccro in Drug Development