The Best Women’s Health Tips on the Planet with Dr. Jennifer Pearlman

<p>What if menopause is one of the most important longevity events in human biology, and we&#39;ve been ignoring it?</p><p><br></p><p>Dr. Matt Kaeberlein sits down with Dr. Jennifer Pearlman, founder of PearlMD and pioneer in female-centric longevity medicine, to unpack why women&#39;s health has been systemically underfunded, undertreated, and misunderstood and what a proactive approach actually looks like.</p><p><br></p><p>From the flawed science behind the Women&#39;s Health Initiative to the nuts and bolts of hormone optimization, testosterone for women, and the emerging field of ovarian tissue cryopreservation, Dr. Pearlman brings 20+ years of clinical expertise and a framework she calls FemSpan: harnessing the unique biology of female longevity while mitigating the risks most medicine ignores.</p><p><br></p><p><strong>Timestamps:</strong></p><p>00:00 — Cold open</p><p>00:47 — Welcome &amp; Dr. Pearlman&#39;s origin story</p><p>02:33 — Why the medical system fails women</p><p>08:37 — How the women&#39;s health landscape has shifted over 20 years</p><p>09:26 — The Women&#39;s Health Initiative: what went wrong</p><p>13:07 — What drove the reemergence of menopause medicine</p><p>14:38 — Big Pharma, funding, and the micronized progesterone question</p><p>17:13 — &quot;Medicine progresses one funeral at a time&quot;</p><p>18:01 — From functional medicine to precision medicine</p><p>20:35 — Rebranding aging: from anti-aging to longevity</p><p>23:50 — Navigating the gray zone between frontier and fringe</p><p>27:46 — How to identify credible practitioners</p><p>33:32 — What every woman should know about the menopause transition</p><p>36:41 — Why take a proactive approach? Symptoms, disease risk, and aging</p><p>38:19 — The two simultaneous biology processes of menopause</p><p>41:46 — The role of FSH and hormone optimization</p><p>43:28 — Estradiol as the body&#39;s regenerative signal</p><p>47:24 — What to test and when</p><p>50:38 — The metabolic theory of menopause</p><p>55:08 — Visceral fat as an evolutionary adaptation</p><p>57:26 — How to navigate hormone therapy</p><p>01:00:24 — Bioidentical hormones: reclaiming the term</p><p>01:06:45 — Why route of administration matters</p><p>01:11:35 — Progesterone: the unsung hero of menopause management</p><p>01:23:19 — Testosterone for women: what the science actually says</p><p>01:34:25 — Introducing FemSpan: the female longevity framework</p><p>01:37:55 — The biological aging advantages women carry</p><p>01:46:46 — Can we close the healthspan gap?</p><p>01:53:05 — Could reversing menopause extend female lifespan?</p><p>02:00:29 — Regenerative medicine and the future of female longevity</p><p>02:03:10 — Ovarian tissue cryopreservation explained</p><p>02:10:39 — AI in women&#39;s precision medicine</p><p>02:15:50 — Medicine at scale: opportunity and risk</p><p>02:21:41 — Advanced cardiovascular diagnostics and the female gap</p><p>02:24:22 — Closing thoughts: your aging trajectory is more in your control than you think</p>