Week in Review | Revita Slows Regain After Tirzepatide at Six Months; Liquidia Settles With United Therapeutics

<p>Fractyl Health reports that its investigational Revita met the six-month co-primary endpoint of the double-blind, sham-controlled REMAIN-1 pivotal study in adults who lost weight on tirzepatide and then stopped it; the twelve-month co-primary is expected in early 2027. Liquidia and United Therapeutics settled all pending patent litigation: Yutrepia stays available for PAH, Liquidia has asked FDA to remove PH-ILD from the label, and total obligations come to $380.7 million. Alex Mercer and Maya Patel cover Revita's safety and missing-data context, then turn to Verdiva's terminated switch-maintenance study, Biomea's BMF-650 Phase 1 data with its confined-placebo caveat, CHMP opinions for Lilly's oral Foundayo and for broadening Tryngolza in severe hypertriglyceridemia, Roche's ALK7 RNAi license from Rona, Zealand's AI-designed protein deal with Generate, and OMass Therapeutics' Series C. Also covered: Alaunos' completed Velaris acquisition and separate private placement; BMS's split admilparant Phase 3 and Syndax's IPF exit; Verastem's KRAS G12D pancreatic cohort and planned first-line Phase 3; CHMP opinions for Rasonque and Talvey; BNT113, Anktiva's papillary-only expansion and Nurix; tab-cel's accepted FDA resubmission; CHMP's confirmed negative opinion on re-examination for Omeros's narsoplimab; KB113 and RYZ101; Modus's sevuparin enrollment pause, Estuary's launch and Novartis's terminated iptacopan lupus nephritis study; maralixibat, obexelimab and garetosmab data; the Zilbrysq autoinjector, ARO-MAPT and Vanda's VQW-765 result and program hold; Anaphylm's FDA review date; FDA approvals for Enspryng in thyroid eye disease and RYZUMVI in presbyopia; interim six-year MIUDELLA data; Galderma's agreement to buy ZO Skin Health; Osivax's flu vaccine result; Pfizer's Enodia deal; IPOs from Iambic and City Therapeutics; China's export-control registration and draft catalog; a CMS proposed rule with PBM provisions; FDA's rare-disease framework initiative; and Marengo's upcoming ESMO presentation. The episode closes on the week's shared CHMP meeting and its different outcomes, the still-open question of weight maintenance after obesity drugs stop, and financings at different stages of completion.</p><p>Alex Mercer and Maya Patel host. Get the daily rundown in your inbox — subscribe at <a href="https://thepharmacloseout.com">thepharmacloseout.com</a>.</p>