NFL Week 5 Preview + Biggest Matchups + DVOA Rankings + Injuries & Upset Alerts

NFL Week 5 is here, and Aaron Schatz and Mike Tanier are breaking down the biggest matchups, injuries, DVOA trends and playoff implications across the weekend.

The spotlight is on the huge NFC West showdown between the San Francisco 49ers and Seattle Seahawks. San Francisco enters Week 5 ranked No. 1 overall in DVOA, while Seattle owns the No. 1 defense in DVOA. With major division-title implications and key injuries on both sides, this could be one of the most important games of the week.

Aaron and Mike also dive into:

🏈 Eagles vs. Jaguars in London

Jacksonville enters at No. 2 in DVOA, while Philadelphia looks to overcome offensive-line issues and improve a struggling rushing attack.

🏈 Raiders at Patriots

A matchup featuring Las Vegas’ surprising pass protection against a New England defense that has been much stronger against the pass than the run.

🏈 Colts at Steelers

Indianapolis brings one of the NFL’s better rushing attacks into Pittsburgh, but the Colts have major concerns in both pass rush and run defense.

🏈 49ers at Seahawks

The biggest game of the show. San Francisco’s top-ranked offense faces Seattle’s No. 1 defense, with major NFC West and playoff implications on the line.

🏈 Ravens at Falcons