Daylight

<p>We chat about the conformational ensembles conference, NIH-proposed policy changes, 4!! preprints, &amp; running. </p><p><br></p><p><strong>NIH news:</strong></p><p><a href="https://www.federalregister.gov/public-inspection/2026-10817/regulation-for-federal-financial-assistance" target="_blank" rel="noopener noreferer">OMB Proposal </a></p><p><a href="⁠https://elizabethginexi.substack.com/p/summary-of-key-changes-in-ombs-proposed⁠ " target="_blank" rel="noopener noreferer">Blog Post Summary on OMB Proposal</a></p><p><a href="https://grants.nih.gov/grants/guide/notice-files/NOT-OD-26-086.html" target="_blank" rel="noopener noreferer">RFI to Cap the Number of Simultaneous Research Project Grants </a></p><p><a href="https://commonfund.nih.gov/earlyindependence" target="_blank" rel="noopener noreferer">Early Independence Award</a></p><p><br></p><p>Preprints:</p><p><a href="https://arxiv.org/abs/2605.14496" target="_blank" rel="noopener noreferer">Detection of residual native state entropy changes upon mutation in Fyn SH3</a></p><p><a href="https://www.biorxiv.org/content/10.64898/2026.05.20.726507v1?rss=1" target="_blank" rel="noopener noreferer">Protein-ligand binding kinetics are primarily controlled by the protein, not the ligand</a></p><p><a href="https://biohub.ai/" target="_blank" rel="noopener noreferer">ESMFold2</a></p><p><a href="https://thestacks.org/publications/sampleworks-release" target="_blank" rel="noopener noreferer">sampleworks: A Modular Platform for Experimentally Guided Biomolecular Ensemble Generation</a></p><p><br></p><p><br></p>