ATF5 Helps Preserve Mitochondrial Quality and Muscle Endurance During Aging

Aging is commonly associated with the gradual loss of skeletal muscle mass and function. While preserving muscle mass is important, muscle health also depends on the mitochondria that provide energy for contraction and help muscles respond to physical stress. A new study suggests that a protein called Activating Transcription Factor 5 (ATF5) plays a complex role in balancing these processes during aging.

A research paper published in Volume 18 of Aging titled “ATF5 is required for the maintenance of mitochondrial homeostasis and skeletal muscle health during aging,” investigated how ATF5 influences mitochondrial quality control, muscle mass, and endurance as mice age.

Full blog - https://aging-us.org/2026/09/atf5-helps-preserve-mitochondrial-quality-and-muscle-endurance-during-aging/

DOI - https://doi.org/10.18632/aging.206365

Corresponding author - David A. Hood - dhood@yorku.ca

Abstract video - https://www.youtube.com/watch?v=u2OeppqIPN4

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Keywords - aging, skeletal muscle, ATF5, mitochondria, stress response

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