Antibodies, patterns and the story of ANA in lupus

In this episode of Rheuminations, host Adam J. Brown, MD, untangles the confusing serologies of lupus by learning about their discoveries from the beginning. He answers questions like what's the deal with immunofluorescence patterns, why does SSA/SSB have two names (Ro/LA), and is double-stranded DNA antibody really attracted to both strands?

·       The story of antibodies in lupus. 3:27

·       The "LE" factor. 10:11

·       The changing fluorescent patterns of the staining of the nucleus/ENAs. 18:50

·       The anti-Smith antibody. 24:51

·       The mysteries of SSA and SSB. 28:52

·       Double-stranded DNA. 36:32

·       Crithidia luciliae. 40:30

We'd love to hear from you! Send your comments/questions to Dr. Brown at rheuminationspodcast@healio.com. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum.

References:

Aarden LA, et al. Ann NY Acad Sci. 1975;doi:10.1111/j.1749-6632.1975.tb29197.x

Alspaugh MA, et al. Arthritis Rheum. 1976;doi:10.1002/art.1780190214